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The principal cytochrome P450 isoenzyme concerned seems to become CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Approximately 85% of the oral dose seems from the urine inside 24 hours of administration, most as the glucuronide conjugate, with tiny quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information.For th